DIAO LAB AT DUKE
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Meet our team

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Yarui Diao, PhD

Principle Investigator
Assistant Professor of Cell Biology

Yarui obtained his B.Sc and PhD from Nanjing University and the Hong Kong University of Science and Technology in 2006 and 2011, respectively.  In 2013, he joined Dr. Bing Ren's lab at UC San Diego as a postdoc fellow to receive the training on genomics and gene regulation. His postdoc work was supported by the prestigious Human Frontier Science Program (HFSP) long-term fellowship. His graduate work was focused on signaling transduction, transcriptional, and epigenetic regulation of myogenesis in muscle stem cell and rhabdomyosarcoma. As a HFSP fellow, he spearheaded the effort to develop high-throughput CRISPR-based genetic screening approaches to identify enhancers from the native chromatin context. He has also made key contribution to generate the 3D cis-regulatory chromatin interaction maps in 27 human tissue and cell types. In the Fall of 2018, with 8 faculty job offers (from 11 interviews) in the U.S., he decided to move to North Carolina and established his independent research program at Duke Cell Biology. As a junior faculty, he continues the effort of developing and deploying cutting-edge function genomics tools to study the gene regulation mechanism of tissue regeneration and cancer development. He is awarded the NIH Genomic Innovator Awards, V Scholar for Cancer Research, Junior faculty award from American Federation for Aging Research (AFAR) and Glenn Foundation, and the Whitehead Scholar of Duke Medical School. He has been a key member of ENCODE and 4D Nucleome consortium, and now serving as Co-Chair of the Cell and Perturbation Working Group of 4DN Consortium. When he is not thinking about research, he might be doing BBQ in his backyard and spending time with his two kids Emily and Olivia.


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Xiaolin Wei, PhD

Postdoctoral fellow
Xiaolin obtained his PhD from Peking University /Tsinghua University /NIBS (PTN) joint program (the best biomedical graduate training program in China). His PhD work with Dr. Xiao Liu was focused to develop novel genome assembly method by designing barcoded BAC libraries. He joined the Diao lab in 2018, and he is our technology guru on genomics technologies. His projects are to develop multi-omics single cell co-assays that can be used to profile chromatin structure and gene expression in complex tissue.


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Tongyu Sun, PhD
Postdoctoral fellow
Tongyu received his PhD training at Shanghai Institutes for Biological Sciences with Dr. Jun Qin to study epigenetic regulation and tumorigenesis. He joined our lab in 2019 and spearheaded the effort to develop CRISPR-BioID proteomic approaches to study mechanism controlling the activity of non-coding regulatory DNA and RNA.


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Xin Lin, PhD
Postdoctoral fellow
Xin received his PhD on Veterinary Medicine at Zhejiang University, China with Dr. Caiqiao Zhang. His graduate work is to study the degradation and functions of the regressed ovarian follicles in chickens. Now he is focused on transcriptional and epigenetic control mechanisms determining skeletal muscle regeneration and rhabdomyosarcoma tumorigenesis.
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Yaneli Guerra Hernandez
Undergraduate student
Yaneli is an undergraduate student at Duke studying Biology along with a focus in Chemistry; additionally she's a national Gates and Questbridge Scholar. She first joined the Diao lab in the summer of 2022 via the BSURF program to pursue her interests in gene regulatory mechanism and its implications in regenerative medicine. She believes in giving back to the community through her organization of free clinics in the local area and volunteering with low resource patients at the Duke Emergency Department.


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Duc Tran
Research technician/lab manager
In 2022, Duc graduated from University of Florida with a B.S. in Biomedical
Engineering and minor in Chemistry. Ultimately, his career goal is to achieve a doctorate degree studying the determinants and
corresponding mechanism of epigenetic changes in stem cell, cancer, and aging. In the Diao lab, he helps the lab management and receives research training in genomics, stem cell biology, and bioinformatics.
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Enxiang Zhang, PhD

Postdoctoral Fellow
Enxiang received his PhD from China Agricultural University in 2020 to study metabolic liver diseases. Prior to joining the Diao lab in Sep 2022, he finished his first postdoc training at Westlake University, mainly working on epigenetic regulation in liver regeneration and liver cancer. His current research focus is to decipher the epigenetic mechanism of muscle injury and regeneration using single-cell multi-omics co-assays.
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Arinze Okafor

PhD student
Arinze was admitted by Duke BME PhD program and is currently a PhD student in Cell Biology. Prior to joining Duke, Arinze received his training in Human Physiology, Genetics, Bioinformatics and Data Science. He believe next generation -omics technologies will play an important role in health and research in the future. Thus, his interests lie at the intersection of Stem Cell Biology, Computational Genomics and Machine Learning. He enjoy integrating these in exploring the complex biology of regeneration and gene regulation among other complex things 🙂. He is awarded the Morton H. Friedman Fellowship from the Department of BME and the Burroughs-Wellcome Graduate Fellowship from School of Medicine. In his free time, he love to sing, cook, and hang out with people.


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Joy Ban, PhD
Postdoctoral fellow
(Co-mentored with Dr. Ben Alman)

Joy finished my Ph.D from Rosa Serra lab in University Alabama at Birmingham.  During her doctoral course, she studied connective tissue development, especially
 TGF-b role in intervertebral disc development, by using mouse model and stem-like cells. After joining Duke, she is studying a disease of connective tissue like sarcoma. She is focusing on the role of epigenetic factors in undifferentiated pleomorphic sarcoma (UPS) metastasis under the guidance of Dr. Alman and Dr. Diao.


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Derek Peters, MD, PhD
Postdoctoral fellow
Derek received his M.D. and Ph.D. from Harvard Medical School and was a member of the Harvard-MIT Program in Health Sciences and Technology (HST). His Ph.D. research in the laboratories of Dr. Chad Cowan and Dr. Kiran Musunuru focused on the application of genome editing and human pluripotent stem cells to characterize genetic variation underlying common human diseases. Derek joined our lab in 2020 as a postdoctoral fellow after completing two years of clinical training in general surgery at Duke. Derek is studying gene regulation during skeletal muscle regeneration and investigating how abnormal regeneration may contribute to the development of human diseases including critical limb ischemia.
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Lizhi Yi, PhD

Postdoctoral fellow
Lizhi received her PhD in Genomics from Beijing Institute of Genomics, Chinese academy of sciences. Her PhD work with Dr. Jiang Liu was focused on early human embryonic development using single cell methylome analysis. The technology that she developed has been applied to a new preimplantation screen platform to analyze the human blastocysts for IVF. She joined the Diao lab in 2022 and she has advantage in genomics. Her project is to study the function and regulation of transposable element in early embryo development using genomics and proteomics approaches.

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Felipe Ferraz
Undergraduate student
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Felipe is currently an undergraduate student at Duke, majoring in Biology with a concentration in genomics and minoring in both computer science and computational biology and bioinformatics. He is a Gates Scholarship Scholar and is set to graduate in 2023, with the hopes of pursuing a PhD in genomics sometime in the future. He joined our lab in 2022 with great enthusiasm and the intention of learning how new computational tools can fundamentally increase our understanding of gene expression and complicated cellular regulatory mechanisms.
LAB ALUMNI

Name                            Diao lab position                              Position after the Diao lab
Inessa CHANDRA         Technician (2018-2019)                         Grad student @ Univ of South California
Yang XU                          Visiting Scholar (2019-2020)               Associate Professor @ Chongqing Medical School, China
Mingkuan Xu                 Undergrad student (2018-2020)        Grad student @ Columbia University
Yu Xiang                         Postdoctoral fellow (2018 - 2022).      Senior Scientist, Bioinformatics @ Singular Genomics, San Diego                 

Contacts
307 Research Drive, 
373/366 Nanaline Duke Building,
​Duke University Medical Center, Box 3709,
Durham, NC 27710
Email: diaolab@duke.edu
Telephone: 919-684-7090
Fax: 919-684-8090

If you are a PhD student and interested in genomics technology development, gene regulation, high-throughput CRISPR, stem cell biology, regeneration, cancer research, bioinformatics and computational biology, please contact us to set up a rotation!
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